QL-IX-55

Short Summary : TORC1/TORC2 inhibitor

Category : PI3K/Akt/mTOR Signaling|mTOR

Purity : 0.98

CAS Number : 1223002-54-7

Formula : C24H14F4N4O

Molecular Weight : 450.39

SMILE : O=C1C=CC2=CN=C3C=CC(C4=CN=C(N)C=C4)=CC3=C2N1C5=CC(C(F)(F)F)=C(F)C=C5

Solubility : DMSO

Storage : Store at -20°C

Description : The functional target of QL-IX-55 is the ATP-binding site of TOR2 as evidenced by the discovery of resistant alleles of TOR2 through rational design and unbiased selection strategies. QL-IX-55 is capable of potently inhibiting both TOR complex 1 and 2 (TORC1 and TORC2) as demonstrated by biochem. IP kinase assays (IC50 <50 nM) and cellular assays for inhibition of substrate YPK1 phosphorylation. In contrast to rapamycin, QL-IX-55 is capable of inhibiting TORC2-dependent transcription, which suggests that this compd. will be a powerful probe to dissect the Tor2/TORC2-related signaling pathway in yeast.

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