RS 504393

Short Summary : CCR2 chemokine receptor antagonist

Category : GPCR/G protein|CCR2

Purity : 0.98

CAS Number : 300816-15-3

Formula : C25H27N3O3

Molecular Weight : 417.5

SMILE : CC1=CC2=C(NC(OC23CCN(CCC4=C(C)OC(C5=CC=CC=C5)=N4)CC3)=O)C=C1

Solubility : Soluble in DMSO > 10 mM

Storage : Store at -20°C

Description : RS 504393 is a selective CCR2 chemokine receptor antagonist (IC50 values are 98 nM and > 100 ?M for inhibition of human recombinant CCR2b and CCR1 receptors respectively). RS 504393 inhibits MCP-1 chemotaxis (IC50 = 330 nM) and ischemia-reperfusion injury in kidneys.

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