TNF-alpha, recombinant human protein

Short Summary : TNF-?, human recombinant, expressed in E. coli, is a 17.4 kDa protein containing 157 amino acid residues, a potent cytokine suitable for cell culture.

Category : Cytokines|Tumor Necrosis Factor

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Storage : Store at -20°C

Description : Tumor Necrosis Factor-? (TNF-?) is a potent cytokine expressed as a 26 kDa transmembrane protein with 233 aa that is cleaved to the soluble 17 kDa monomer by TNF-? converting enzyme (TACE) and forms stable homotrimers. TNF-? is expressed in many cells and plays an important role in inflammation, immune modulation, septic shock, viral replication, antitumor activity, anorexia, cachexia and hematopoiesis. TNF-? is chiefly produced by macrophages when challenged with viruses or bacteria. TNF-? is cytotoxic for many tumor cells lines but induced activation, differentiation or proliferation in normal cells. Tumor necrosis factor receptor TNFR1 and TNFR2 are receptors for TNF-?.

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