TNF-alpha, recombinant murine protein

Short Summary : TNF-?, expressed in E. coli, suitable for cell culture.

Category : Cytokines|Tumor Necrosis Factor

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Storage : Store at -20°C

Description : Tumor Necrosis Factor-? (TNF-?) is a potent cytokine expressed as a transmembrane protein with 235 aa that is cleaved to the soluble monomer by TNF-? converting enzyme (TACE) and forms stable homotrimers. TNF-? is expressed in many cells and plays an important role in inflammation, viral replication, tumorigenesis, apoptosis, cell proliferation, differentiation, coagulation and lipid metabolism. TNF-? is mainly produced by macrophages when challenged with viruses or bacteria. TNF-? is cytotoxic for many tumor cells lines but induced activation, differentiation or proliferation in normal cells. Tumor necrosis factor receptor TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR are receptors for murine TNF-?.

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