Tyrphostin 9

Short Summary : Selective EGFR/PDGFR inhibitor

Category : Tyrosine Kinase|VEGFR

Purity : 0.9968

CAS Number : 10537-47-0

Formula : C18H22N2O

Molecular Weight :

Molecular Weight : 282.38

SMILE : CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)C=C(C#N)C#N

Solubility : >14.1mg/mL in DMSO

Storage : Store at -20°C

Description : Tyrphostin 9 is an inhibitor of PDGFR with IC50 value of ~2.5M [1].Tyrphostin 9 is generated as specific inhibitor of PDGFR in 1991. It also has inhibitory effect on the proliferation of SMC. Tyrphostin 9 potently inhibits the PDGF-dependent SMC proliferation with IC50 value of 40nM and inhibits the PDGF-dependent autophosphorylation of PDGFR with IC50 value of ~2.5M. Besides that, Tyrphostin 9 also affects the phosphorylation of PLC (IC50 value of about 2.5M) and the PDGF-dependent c-fos expression. Moreover, Tyrphostin 9 is found to be an inhibitor of EGFR with IC50 value of 460M [1, 2]. In the rat carotid artery injury model, treatment of Tyrphostin 9 significantly reduces neointimal hyperplasia through inhibiting the tyrosine phosphorylation in injured arteries [1].References:[1] Levitzki A. PDGF receptor kinase inhibitors for the treatment of restenosis. Cardiovascular research, 2005, 65(3): 581-586.[2] Levitzki A. Tyrphostinspotential antiproliferative agents and novel molecular tools. Biochemical pharmacology, 1990, 40(5): 913-918.

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