Bavisant

Short Summary : Human H3 receptor antagonist

Category : Neuroscience|Histamine Receptor

Purity : 0.98

CAS Number : 929622-08-2

Formula : C19H27N3O2

Molecular Weight : 329.44

SMILE : O=C(C1=CC=C(CN2CCOCC2)C=C1)N(CC3)CCN3C4CC4

Solubility : 25℃: DMSO

Storage : Store at -20°C

Description : Description:
IC50 Value: N/A
Bavisant (JNJ-31001074) is a highly selective, orally active antagonist of the human H3 receptor with a novel mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD. Bavisant completed a phase II ADHD trial, but no results have been reported [1].
in vitro: N/A
in vivo: Mean change from baseline in the total ADHD-RS-IV score at day 42 (primary efficacy endpoint) was -8.8 in the placebo group versus -9.3, -11.2 and -12.2 in the bavisant 1 mg/day, 3 mg/day and 10 mg/day groups, respectively; the change in the 10 mg/day group was not statistically superior to placebo (p=0.161), and hence statistical comparisons of the 1 mg/day and 3 mg/day groups with placebo based on a step-down closed testing procedure were not performed [2].
Clinical trial: A Study to Characterize the Pharmacokinetics and Effect of Food on JNJ-31001074 in Healthy Volunteers. Phase 2

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