Biotin-Geldanamycin (Hsp90 Inhibitor)

Stressmarq Biosciences

Geldanamycin is a benzoquinoid ansamycin produced by Streptomyces hygroscopicus. It binds specifically to heat shock protein HSP90 and downregulates target proteins including tyrosine kinases, steroid receptors, transcription factors and cell cycle regulatory kinases (1,2). It induces the inactivation, destabilization and eventual degradation of HIF-1á (3).This inhibitor is a useful tool for affinity purification of HSP-90 and HSP-90 dependent client proteins (4).

Selected References

1. Whitesell L., et al. (1994) Proc. Natl Acad. Sci. USA 91:8324.

2. Neckers L. (2002) Trends Mol. Med. 8: S55.

3. Mabjeesh N.J., et al. (2002) Cancer Res. 62: 2478.

4. Clevenger R.C. et al. (2004) J. Org. Chem. 69: 4375.


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