Histatin 5

Category : Antimicrobial and Related Peptides

Purity : 95%

Sequence (One Letter Code) : DSHAKRHHGYKRKFHEKHHSHRGY

Sequence (Three letter Code) : {ASP}{SER}{HIS}{ALA}{LYS}{ARG}{HIS}{HIS}{GLY}{TYR}{LYS}{ARG}{LYS}{PHE}{HIS}{GLU}{LYS}{HIS}{HIS}{SER}{HIS}{ARG}{GLY}{TYR}

Histatin 5 is a human basic salivary peptide with strong fungicidal properties in vitro. To elucidate the mechanism of action, the effect of histatin 5 on the viability of Candida albicans cells was studied in relation to its membrane perturbing properties. It was found that both the killing activity and the membrane perturbing activity, studied by the influx of a DNA-specific marker propidium iodide, were inhibited by high salt conditions and by metabolic inhibitors, like sodium azide.

Mol Wt : 3036.29