Human Phospho-Caspace9 (S196) mAb

Mgenex Biosciences

Specificity: Human phospho-Caspase 9 (S196)

Source: Rabbit

IgG Type: rabbit IgG

Background: Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Heterodimer of a 35 kDa (p35) and a 10 kDa (p10) subunit. Caspase-9 and APAF1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the presence of cytochrome C and ATP. Interacts with the inhibitors BIRC2, BIRC4, BIRC5 and BIRC7.

Other Name: Caspase-9

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0.1 mg

£0.01 / €0.01 MG1603

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