Human Phospho-JNK (T183/185) mAb
Specificity: Human phospho-JNK (T183/T185)
IgG Type: rabbit IgG
Background: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells.
Other Name: Stress-activated protein kinase JNK
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