Human Phospho-P27/Kip1 (T57) mAb

Specificity: Human phospho-P27/Kip1 (T157)

Source: Rabbit

IgG Type: rabbit IgG

Background: Involved in G1 arrest. May mediate TGF beta-induced G1 arrest. Binds to and inhibits complexes formed by cyclin E-CDK2, cyclin A-CDK2, and cyclin D1-CDK4.

Interaction with nucleoporin NUP50 is required for nuclear import and for degradation of phosphorylated p27Kip1 after nuclear import.

Other Name: Cyclin-dependent kinase inhibitor p27Kip1