Human Phospho-P27/Kip1 (T57) mAb
Specificity: Human phospho-P27/Kip1 (T157)
IgG Type: rabbit IgG
Background: Involved in G1 arrest. May mediate TGF beta-induced G1 arrest. Binds to and inhibits complexes formed by cyclin E-CDK2, cyclin A-CDK2, and cyclin D1-CDK4.
Interaction with nucleoporin NUP50 is required for nuclear import and for degradation of phosphorylated p27Kip1 after nuclear import.
Other Name: Cyclin-dependent kinase inhibitor p27Kip1
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