STIM2 (CT) Antibody

Pro Sci


In T lymphocytes, the sole pathway for Ca++ entry following antigen-receptor binding is through store-operated Ca++-release-activated Ca++ (CRAC) channels. These channels are made up of the pore-forming subunit ORAI1 and the stromal interaction molecule 1 (STIM1), a protein that functions as a Ca++ sensor and activates the CRAC channels, migrating to the plasma membrane from endoplasmic reticulum (ER)-like sites which act as the Ca++ store. A related molecule, STIM2, acts to inhibit the STIM1-mediated store-operated Ca++ entry, and can form complexes with STIM1, suggesting they may play a coordinated role in controlling Ca++ entry. At least three isoforms of STIM2 are known to exist. This STIM2 antibody is predicted to have no cross-reactivity to STIM1.

Additional Names

STIM2 (CT), Stromal interaction molecule 2


STIM2 antibody was raised against an 18 amino acid peptide from near the carboxy terminus of human STIM2.


Affinity chromatography purified via peptide column

Clonality / Clone

This is a polyclonal antibody.


STIM2 antibody was raised in rabbit.

Please use anti-rabbit secondary antibodies.


STIM2 antibody can be used for detection of STIM2 by Western blot at 0.5 – 1 μg/ml.

Tested Application



Antibody is supplied in PBS containing 0.02% sodium azide.

Blocking Peptide

Cat.No. 4123P – STIM2 Peptide


STIM2 antibody can be stored at 4˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Positive Control

  1. Cat. No. 1288 – A20 Cell Lysate
  2. Cat. No. 1306 – Human Spleen Tissue Lysate

Species Reactivity

H, M, R

Protein GI Number


Protein Accession Number


Short Description

(CT) an inhibitor of STIM1

This product belongs to the following categories:

  • Antibodies
  • Polyclonal Antibodies
  • Immunology Antibodies

Related Products

  • A-20 Cell Slide
    (Catalog No. 17-208).
  • A-20 Lysate
    (Catalog No. 1288).
  • ORAI1 Antibody
    (Catalog No. 4041).
  • ORAI2 Antibody
    (Catalog No. 4111).
  • ORAI3 Antibody
    (Catalog No. 4215).
  • ORAI3 Antibody
    (Catalog No. 4117).
  • Spleen Lysate
    (Catalog No. 1306).
  • Spleen Tissue Slide (Normal)
    (Catalog No. 10-901).
  • STIM1 Antibody
    (Catalog No. 4119).
  • STIM2 Antibody
    (Catalog No. 4125).
  • STIM2 Peptide
    (Catalog No. 4123P).


  1. Luik RM and Lewis RS. New insights into the molecular mechanisms of store-operated Ca2+ signaling in T cells. Trends Mol. Med. 2007; 13:103-7.
  2. Feske S, Gwack Y, Prakriya M, et al. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature 2006; 441:179-85.
  3. Zhang SL, Yu Y, Roos J, et al. STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane. Nature 2005; 437:902-5.
  4. Spassova MA, Soboloff J, He L-P, et al. STIM1 has a plasma membrane role in the activation of store-operated Ca2+ channels. Proc. Natl. Acad. Sci. USA 2006; 103:4040-5.

Datasheet 08-02W

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£295.00 / €413.00 4123

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